Heart failure & cardiomyopathies
Cardiopulmonary Exercise Testing Predicts Prognosis in Amyloid Cardiomyopathy: A Systematic Review and Meta-Analysis
Authors' conclusion
CPET is a valuable tool for prognostic stratification in CA, identifying patients at increased risk of death.
Study context
- Population
- Patients with transthyretin or light-chain cardiac amyloidosis undergoing cardiopulmonary exercise testing (CPET)3 studies in meta-analysis
- Participants
- 233 patients
- Outcome
- Association of peak VO2 and VE/VCO2 slope with mortality
Methodological detailsrandom-effect model, 5 studies in qualitative analysis, 3 in quantitative analysis
- Random-effect model
- 5 studies in qualitative analysis, 3 in quantitative analysis
Pooled result
As reported in the abstract
Risk of death
Pooled hazard ratio (95% CI)
Peak VO2
0.89(0.84–0.94)
VE/VCO2 slope
1.04(1.01–1.07)
Further pooled results
CPET variables
- Mean peak VO2 consistently depressed; VE/VCO2 slope increased
Original publication
Cardiopulmonary Exercise Testing Predicts Prognosis in Amyloid Cardiomyopathy: A Systematic Review and Meta-Analysis. ESC Heart Fail. Published 1 June 2023. doi:10.
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