Association of Lipoprotein(a) With Cardiovascular and Cerebrovascular Disease in a Nationally Representative Cohort of Germany
An erratum to this article was published (JACC Adv, Jan 2026 ↗)
Authors' conclusion
About 1 in 5 German individuals from a prestatin era population had Lp(a) levels ≥50 mg/dL. Higher levels were independently associated with ASCVD, but not with venous thrombosis. These findings provide a basis for future prospective studies to define the role of Lp(a) in CVD risk in the German population.
Study context
- Population
- German adult population, 1997 to 1999German National Health Interview and Examination Survey 1998
- Participants
- 6,657 participants
- Exposure
- Lp(a) on continuous scales and as dichotomous thresholds vs history of self-reported cardiovascular disease (CVD)
- Outcome
- Lp(a) distribution
Main finding
As reported in the abstract
Median Lp(a)
15.3 mg/dL
Q1-Q3: 5.6, 43.1
Lp(a) levels ≥50 mg/dL
21.6%
Observational data: associations, not effects.
Further findings
Median Lp(a) by sex
History of atherosclerotic cardiovascular disease (ASCVD)
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| Lp(a) ≥50 mg/dLLogistic regression | 1.36 (1.04–1.78) | P = 0.023 | |
| 0.512Odds ratio (log scale) |
Median Lp(a) by history of ASCVD and venous thrombosis
- Significantly higher in individuals with than without a history of ASCVD
- Did not significantly differ between people with and without venous thrombosis
History of CVD (logistic regression with splines)
- Higher Lp(a) levels associated with a higher probability of a history of CVD
Original publication
Summarised from the published abstract; every number is checked against it