The association of lipoprotein(a) and coronary artery calcium in asymptomatic patients: a systematic review and meta-analysis
Authors' conclusion
Our findings of this meta-analysis suggest that Lp(a) is positively associated with a higher likelihood of CAC. Higher Lp(a) levels increased the odds of CAC >0.
Study context
- Population
- Asymptomatic patients (mean age 55.9 years, 46.4% female)
- Participants
- 23,105 patients · 18 studies
- Comparison
- Elevated Lp vs not elevated
- Outcome
- CAC > 0 Agatston units and CAC ≥ 100
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
CAC > 0 and CAC ≥100
Elevated Lp(a)Odds ratio (95% CI)P value
CAC > 0
1.31(1.05–1.64)
P = 0.02CAC ≥100
1.29(1.01–1.65)
P = 0.04Further pooled results
Coronary artery calcium (CAC) progression
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| Elevated Lp(a) | 1.43 (1.20–1.70) | P < 0.01 | |
| 0.512Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| CAC > 0 per 1 mg/dL increment in Lp(a) | 1.01 (1.01–1.01) | P < 0.01 | |
| 0.512Odds ratio (log scale) |
Original publication
The association of lipoprotein(a) and coronary artery calcium in asymptomatic patients: a systematic review and meta-analysis. Eur J Prev Cardiol. Published 1 February 2024. doi:10.
Summarised from the published abstract; every number is checked against it