Association of Lipoprotein(a) With Major Adverse Cardiovascular Events Across High-sensitivity C-reactive Protein (hs-CRP): A Systematic Review and Meta-Analysis
Authors' conclusion
Elevated Lp(a) is associated with an increased risk of MACE independent of hs-CRP levels in both primary and secondary prevention populations.
Study context
- Population
- Primary and secondary prevention populations; studies reporting Lp(a)–major adverse cardiovascular events (MACE) association stratified by hs-CRP
- Participants
- 562,301 participants · 11 studies
- Comparison
- Elevated Lp, stratified by hs-CRP level
- Outcome
- MACE
Methodological detailsrandom-effects models
- Random-effects models
Pooled result
As reported in the abstract
MACE with elevated Lp(a)
Pooled hazard ratio (95% CI)
Low hs-CRP
1.26(1.11–1.42)
High hs-CRP
1.33(1.20–1.47)
Further pooled results
MACE with elevated Lp(a), primary prevention (subgroup)
| Comparison | Pooled HR (95% CI) | |
|---|---|---|
| Low hs-CRP | 1.33 (1.06–1.66) | |
| High hs-CRP | 1.43 (1.13–1.82) | |
| 0.512Pooled hazard ratio (log scale) |
MACE with elevated Lp(a), secondary prevention (subgroup)
| Comparison | HR (95% CI) | |
|---|---|---|
| Low hs-CRP | 1.13 (1.00–1.27) | |
| High hs-CRP | 1.31 (1.12–1.52) | |
| 0.512Hazard ratio (log scale) |
- MACE with elevated Lp(a), primary prevention (subgroup): subgroup difference P = 0.65
- MACE with elevated Lp(a), secondary prevention (subgroup): subgroup difference P = 0.13
Original publication
Association of Lipoprotein(a) With Major Adverse Cardiovascular Events Across hs-CRP: A Systematic Review and Meta-Analysis. JACC Adv. Published 19 November 2024. doi:10.
Summarised from the published abstract; every number is checked against it