Heart failure & cardiomyopathies
Association of Mild Kidney Dysfunction with Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction
Main finding · HFpEF prevalenceResult — go to the resultOdds ratio 2.07 95% CI 1.23–3.49Authors' conclusion
Both mild and moderate kidney dysfunction are independently associated with left ventricular diastolic dysfunction parameters and HFpEF. This association is independent of sex and strongest for moderate kidney dysfunction.
Study context
- Population
- Outpatients in the HELPFul observational study; mean age 62.9 years, 69% female406 with mild or moderate kidney dysfunction
- Participants
- 880 outpatients
- Exposure
- Mild or moderate kidney dysfunction vs normal kidney function
- Outcome
- E/e', LV mass index, relative wall thickness, ACC/AHA stage C/D HF and HFpEF (expert panel)
Methodological detailsmultivariable adjusted regression, sex-stratified
- Multivariable adjusted regression
- Sex-stratified
Main finding
HFpEF prevalence
Odds ratio
2.07
95% CI 1.23–3.49
By group
Moderate kidney dysfunctionvs Normal kidney function
OR 2.07 (95% CI 1.23–3.49)
As reported in the abstract
Observational data: associations, not effects.
Original publication
Association of Mild Kidney Dysfunction with Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 27 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →