Association of obesity subphenotypes with indices of cardiac remodeling in the Framingham heart study
Authors' conclusion
Increasing body weight was associated with adverse cardiac remodeling regardless of metabolic health status, which suggests that obesity may directly increase the risk of adverse cardiac remodeling.
Study context
- Population
- Framingham Heart Study participants without prevalent CVD who underwent echocardiography; mean age 49 years, 55% women6 obesity subphenotypes
- Participants
- 6,639 participants
- Exposure
- Overweight and obesity vs normal weight, by metabolic health status
- Outcome
- Echocardiographic measures of cardiac remodeling
Methodological detailsFramingham Heart Study cohort, multivariable regression
- Framingham Heart Study cohort
- Multivariable regression
Main finding
As reported in the abstract
Echocardiographic remodeling among metabolically healthy participants vs normal weight
| Outcome | Overweight | Obese |
|---|---|---|
| LV mass increase | 11.6 gm | 21.4 gm |
| Left atrium end-systolic dimension increase | 0.27 cm | 0.48 cm |
| Global longitudinal strain increase | 0.82% | 1.06% |
| E/e' ratio increase | 0.35 | 0.87 |
| Mitral annular plane systolic excursion | — not stated in the abstract | 0.08 cm |
| Relative wall thickness | — not stated in the abstract | 0.01 |
— not stated in the abstract
Observational data: associations, not effects.
Original publication
Association of obesity subphenotypes with indices of cardiac remodeling in the Framingham heart study. Am Heart J. Published 19 October 2025. doi:10.
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