Heart failure & cardiomyopathies
Association of Perivascular Fat Attenuation on Computed Tomography and Heart Failure with Preserved Ejection Fraction
Authors' conclusion
High PCATA score was significantly associated with the presence of HFpEF.
Study context
- Population
- Outpatients undergoing echocardiography and coronary CT angiography, without obstructive CAD
- Participants
- 607 outpatients
- Exposure
- Heart failure with a preserved ejection fraction (HFpEF) vs no HFpEF
- Outcome
- Association between PCATA on coronary CT angiography and presence of HFpEF
Main finding
As reported in the abstract
PCATA (proximal 40-mm segments)
HFpEF
- LAD
- −65.2 ± 6.9
- LCX
- −62.7 ± 6.8
- Right coronary artery (RCA)
- −63.6 ± 8.5
Control
- LAD
- −68.1 ± 6.7
- LCX
- −65.4 ± 6.6
- RCA
- −65.5 ± 7.7
LAD
HFpEF−65.2 ± 6.9
Control−68.1 ± 6.7
LCX
HFpEF−62.7 ± 6.8
Control−65.4 ± 6.6
Right coronary artery (RCA)
HFpEF−63.6 ± 8.5
Control−65.5 ± 7.7
Odds ratio (95% CI)
LAD-PCATA per SD
1.449(1.152–1.823)
LCX-PCATA per SD
1.634(1.283–2.081)
RCA-PCATA per SD
1.388(1.107–1.740)
Per SD, as printed
Observational data: associations, not effects.
Further findings
Pericoronary adipose tissue attenuation (PCATA)–HFpEF association across clinical subgroups
- Mostly consistent across various patient clinical characteristics
Correlation of LV mass and LA volume index with PCATA
- LV mass vs LAD-PCATA
- ρ = 0.13 [P < 0.01]
- LA volume index vs LAD-PCATA
- ρ = 0.24 [P < 0.01]
- LV mass vs LCX-PCATA
- ρ = 0.16 [P < 0.01]
- LA volume index vs LCX-PCATA
- ρ = 0.23 [P < 0.01]
- Mild correlation
Original publication
Association of Perivascular Fat Attenuation on Computed Tomography and Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 31 May 2023. doi:10.
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