Cross-sectional study
Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives
- Cross-sectional study
- multicentre (25 sites)
Authors' conclusion
Cardiovascular screening identified new DCM-related findings among 1 in 7 reportedly unaffected FDRs regardless of race and ethnicity, underscoring the value of clinical screening in all FDRs.
Study context
- Population
- Adult reportedly unaffected first-degree relatives (FDRs) of patients with dilated cardiomyopathy (DCM)
- Participants
- 1,365 participants
- Outcome
- Yield of clinical screening (echocardiogram and ECG): new DCM, LV systolic dysfunction or LV enlargement
Main finding
As reported in the abstract
New diagnoses of DCM, LVSD or LVE on screening
Any new diagnosis
14.1%
DCM
2.1%
Left ventricular systolic dysfunction (LVSD)
3.6%
Left ventricular enlargement (LVE)
8.4%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Any finding, age-adjusted, by race and ethnicity | Hispanic 16.2% · Non-Hispanic Black 15.2% · Non-Hispanic White 13.1% |
| Any finding, age-adjusted, by sex | Women 14.6% · Men 12.8% |
Any finding, age-adjusted, by race and ethnicity
- Did not differ statistically by race and ethnicity
Any finding, age-adjusted, by sex
- Did not differ statistically by sex
Other associations with findings
- New diagnoses higher at age 45–64 than 18–44 years
- Any finding higher with hypertension and obesity (age-adjusted)
- FDRs of probands with clinically reportable variants more likely identified with DCM
Original publication
Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives. J Am Coll Cardiol. Published 30 May 2023. doi:10.1016/j.jacc.2023.03.419
Summarised from the published abstract; every number is checked against it