Pulmonary vascular disease & thromboembolism
Association of Pulmonary Artery Compliance and Adverse Cardiac Events
Authors' conclusion
Among patients undergoing right heart catheterization, lower PAC is associated with adverse outcomes irrespective of PH status.
Study context
- Population
- Ambulatory and hospitalised patients undergoing right heart catheterization, single centre, 2005–2016
- Participants
- 7,966 participants
- Exposure
- Higher vs lower pulmonary artery compliance
- Outcome
- HF hospitalization and mortality
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
PAC (per 1-SD higher)Hazard ratio (95% CI)
Mortality
0.59(0.56–0.63)
HF hospitalization
0.56(0.52–0.59)
Per 1-SD higher, as printed
- Median pulmonary artery compliance (PAC)
- 3.29 mL/mm Hg (Q1-Q3: 2.19-4.70 mL/mm Hg)
Observational data: associations, not effects.
Further findings
Mortality and heart failure (HF) hospitalization, by pulmonary hypertension (PH) status (subgroup)
| HR (95% CI) | ||
|---|---|---|
| PACWith PH: mortality | 0.69 (0.64–0.74) | |
| PACWith PH: HF hospitalization | 0.65 (0.61–0.70) | |
| PACWithout PH: mortality | 0.74 (0.66–0.84) | |
| PACWithout PH: HF hospitalization | 0.72 (0.61–0.85) | |
| 0.512Hazard ratio (log scale) |
Mortality, by PH subtype (subgroup)
| HR (95% CI) | ||
|---|---|---|
| PACPrecapillary PH | 0.56 (0.48–0.65) | |
| PACCombined PH | 0.75 (0.66–0.86) | |
| PACPostcapillary PH | 0.88 (0.79–0.98) | |
| 0.512Hazard ratio (log scale) |
Original publication
Association of Pulmonary Artery Compliance and Adverse Cardiac Events. JACC Adv. Published 27 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →