Heart failure & cardiomyopathies
Association of secondary mitral regurgitation and right ventricular dysfunction among patients with non-ischaemic cardiomyopathy
Authors' conclusion
In patients with NICM, the severity of secondary MR is associated with an increased prevalence of RV dysfunction. The RV dysfunction is not only associated with the severity of LV dysfunction but also with the severity of secondary MR.
Study context
- Population
- HF patients with non-ischaemic cardiomyopathy (NICM), prospective registry 2008–2019, assessed by cardiac magnetic resonance (CMR)
- Participants
- 241 patients
- Exposure
- Right ventricular (RV) dysfunction vs no RV dysfunction
- RV dysfunctionn = 148
- Outcome
- Association of secondary mitral regurgitation (MR) with RV dysfunction (RVEF <45%)
Main finding
As reported in the abstract
Secondary MR severity (CMR)
Odds ratio (95% CI)P value
MR volume ≥ 24 mL
3.21(1.26–8.15)
P = 0.01MR fraction ≥ 30%
5.46(2.23–13.35)
P = 0.002- RV dysfunction prevalence
- 148 (61%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Composite of all-cause death, heart transplantation or LV assist device implantation, per 1% increase in RVEF · follow-upIndependent association | 0.98 (0.95–1.00) | P = 0.047 | |
| 0.512Hazard ratio (log scale) |
Original publication
Association of secondary mitral regurgitation and right ventricular dysfunction among patients with non-ischaemic cardiomyopathy. Eur Heart J Cardiovasc Imaging. Published 23 May 2024. doi:10.
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