Association of T-Cell Phenotypes With Peri-Coronary Inflammation in People With and Without HIV and Without Cardiovascular Disease
Authors' conclusion
The associations between T-cell activation with FAI are novel and suggest that T-cell activation may be an important driver of peri-coronary inflammation, occurring at an early stage of atherosclerosis, even before the development of clinical disease.
Study context
- Population
- People with and without HIV without known CVD who underwent coronary CT angiography with fat attenuation index (FAI) measurement
- Participants
- 58 vs 16
- Exposure
- People with HIV vs people without HIV
- HIVn = 58
- Without HIVn = 16reference
- Outcome
- Associations of T-cell activation and phenotypes with FAI (peri-coronary inflammation) of the right coronary artery and left anterior descending artery
Methodological detailscross-sectional analysis of an observational cohort, multivariable regression adjusted for age, natal sex, race, LDL-C, BMI, lipid-lowering medication
- Cross-sectional analysis of an observational cohort
- Multivariable regression adjusted for age, natal sex, race, LDL-C, BMI, lipid-lowering medication
Main finding
As reported in the abstract
Associations of T-cell phenotypes with FAI
- Among all participants, PD-1 in CD8 central memory associated with worsened peri-coronary inflammation of the right coronary artery
- Perforin/granzyme B on CD8 TEM associated with improved peri-coronary inflammation of the right coronary artery and left anterior descending artery
- Accounting for HIV serostatus, CD38/HLA-DR coexpression on CD8 central memory, TEM and terminally-differentiated effector memory cells associated with more peri-coronary inflammation of the left anterior descending artery
- Adjusted analyses
Observational data: associations, not effects.
Further findings
T-cell activation and CCR2 expression, HIV vs without HIV
- Greater CD38/HLA-DR coexpression on CD4 central memory and terminally-differentiated effector memory subsets and CD8 TEM with HIV
- Reduced CCR2 expression on CD4 central memory and TEM and CD8 TEM and terminally-differentiated effector memory subsets with HIV
Original publication
Association of T-Cell Phenotypes With Peri-Coronary Inflammation in People With and Without HIV and Without Cardiovascular Disease. Circ Cardiovasc Imaging. Published 6 December 2024. doi:10.
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