Heart failure & cardiomyopathies
Association of Tricuspid Regurgitation With Mortality in Heart Failure With Left-Sided Heart Disease
Authors' conclusion
TR severity stratified mortality after acute decompensated HF better in patients without LVD than in those with LVD.
Study context
- Population
- Patients hospitalized for Heart Failure (HF) in the West Tokyo Heart Failure registry, January 2006 to December 2021
- Participants
- 3,040 vs 2,438
- Exposure
- Moderate and severe tricuspid regurgitation (TR) vs no TR, in patients with and without LVD
- LVDn = 3,040
- No LVDn = 2,438
- Outcome
- Prevalence of moderate and severe TR
Methodological detailsmulticenter, multivariable Cox hazard model
- Multicenter
- Multivariable Cox hazard model
Main finding
As reported in the abstract
Moderate TR
Severe TR
Observational data: associations, not effects.
Further findings
Mortality
| Adjusted HR (95% CI) | ||
|---|---|---|
| Moderate TRIn those with LVD | 1.25 (1.03–1.52) | |
| Severe TRIn those with LVD | 1.72 (1.30–2.29) | |
| Moderate TRIn those without LVD | 2.15 (1.62–2.84) | |
| Severe TRIn those without LVD | 3.09 (1.87–5.09) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- Mortality: Significant interactions between the subtypes were observed (P = 0.005)
Original publication
Association of Tricuspid Regurgitation With Mortality in Heart Failure With Left-Sided Heart Disease. JACC Adv. Published 26 May 2025. doi:10.
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