Heart failure & cardiomyopathiesCross-sectional study
Prevalence of Heart Failure with Preserved Ejection Fraction (HFpEF) in Isolated Severe Secondary Tricuspid Regurgitation
- Retrospective cross-sectional study
- single-centre
- consecutive patients
Authors' conclusion
The findings suggest that HFpEF is underdiagnosed and should be rigorously evaluated for in patients with severe isolated STR, along with precapillary PH, as both have distinct requirements for management.
Study context
- Population
- Adults with severe isolated secondary TR (no EF <50%, left-sided valve disease, congenital, infiltrative/hypertrophic cardiomyopathy, pericardial disease or prior cardiac procedures) undergoing rest-and-exercise right heart catheterization (RHC), Mayo Clinic, 2006–2023
- Participants
- 54 adults
- Outcome
- Prevalence of HFpEF and precapillary pulmonary hypertension
Main finding
As reported in the abstract
HFpEF identified
40 patients (74%)
HFpEF recognised before RHC
19 patients (35%)
Precapillary pulmonary hypertension (PH) among the 14 without HFpEF
10 (71%)
Observational data: associations, not effects.
Further findings
| Outcome | Left atrial emptying fraction | Left atrial strain |
|---|---|---|
| Discrimination of noninvasive measures for HFpEF | ||
| AUC | 0.90 (95% CI, 0.82-0.98) | 0.91 (95% CI, 0.83-0.99) |
Guideline-defined diastolic dysfunction absent in patients diagnosed with HFpEF
- Diastolic dysfunction (DD) absent
- 24 patients (60%)
Original publication
Prevalence of HFpEF in Isolated Severe Secondary Tricuspid Regurgitation. JAMA Cardiol. Published 1 February 2025. doi:10.1001/jamacardio.2024.3767
Summarised from the published abstract; every number is checked against it