Aortic & peripheral vascular disease
Association of Statin Treatment and Dose With the Clinical Course of Small Abdominal Aortic Aneurysms in Men: A 5-Year Prospective Cohort Study From 2 Population-Based Screening Trials
Main finding · AAA growth rate per increase of 1 DDD statin per dayResult — go to the resultAdjusted change in growth rate −0.22 mm/year 95% CI −0.39 to −0.06Authors' conclusion
High-dose statin use was associated with decreased AAA growth rates and lowered risk of undergoing repair, rupture, and death.
Study context
- Population
- Men with screening-detected abdominal aortic aneurysms (AAAs) (30–55 mm), Viborg Vascular Screening trial and Danish Cardiovascular Screening trial
- Participants
- 998 men
- Exposure
- Statin dose and AAA course
- Outcome
- AAA growth rate
Methodological detailsmen from 2 population-based randomised screening trials, Danish Healthcare Registries linkage
- Men from 2 population-based randomised screening trials
- Danish Healthcare Registries linkage
Main finding
As reported in the abstract
AAA growth rate per increase of 1 defined daily doses (DDD) statin per day
Adjusted change in growth rate
−0.22 mm/year
95% CI −0.39 to −0.06
P = 0.009
+1 DDD statin per day
adjusted change in growth rate −0.22 mm/year (95% CI −0.39 to −0.06); P = 0.009
Per day, as printed
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Repair per doubling of statin dose · 5 yearsSignificant after 2.5 years | 0.82 (0.70–0.97) | P = 0.023 | |
| Composite of surgery, rupture and death per doubling of statin dose | 0.83 (0.73–0.94) | P = 0.003 | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Association of Statin Treatment and Dose With the Clinical Course of Small Abdominal Aortic Aneurysms in Men: A 5-Year Prospective Cohort Study From 2 Population-Based Screening Trials. Circulation. Published 9 July 2025. doi:10.
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