Associations between circulating proteins and cardiometabolic diseases: a systematic review and meta-analysis of observational and Mendelian randomisation studies
Authors' conclusion
Combined analyses of observational and genetic studies revealed the potential causal role of several proteins in the aetiology of CMD.
Study context
- Population
- Prospective observational and Mendelian randomisation (MR) studies of circulating proteins and cardiometabolic diseases (CMD) (CHD, stroke, T2DM, HF, AF, atherosclerosis)50 observational, 25 MR, 10 both
- Participants
- 26,414,160 participants
- Outcome
- Observational and genetic associations between circulating proteins and CMD
Methodological detailsrandom effects models, Searched PubMed, Embase and Web of Science until July 2023, Two investigators independently extracted data
- Random effects models
- Searched PubMed, Embase and Web of Science until July 2023
- Two investigators independently extracted data
Pooled result
As reported in the abstract
- Proteins associated with CMD (observational meta-analysis)
- 560
- Pleiotropic proteins (associated with ≥2 CMDs), observational
- 133
- Potentially causal protein biomarkers (MR pooled)
- 245
- Pleiotropic proteins among MR causal proteins
- 23
- IL6RA and MMP12 each causally associated with seven diseases
- 7
- Protein-disease pairs directionally concordant in observational and MR estimates
- 22
Further pooled results
Prediction of incident CMD: protein biomarkers added to traditional clinical models
- Modest improvement; highest for HF (ΔC-index)
- ≈0.2
Drug development evidence for potentially causal proteins (291 protein-disease pairs)
- Pairs validated by drug development evidence
- 3
- Pairs lacking drug development evidence
- 288
- Proteins that are drug targets approved for other indications
- 66
Original publication
Associations between circulating proteins and cardiometabolic diseases: a systematic review and meta-analysis of observational and Mendelian randomisation studies. Heart. Published 31 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →