Prevention & lipidsResearch article
Associations of Left Atrial Dimension and Ventricular Mass With Long-Term Health Outcomes
- Framingham participants
- community-based sample
- up to 3 serial echocardiographic observations
Authors' conclusion
In our large community-based sample, we observed associations of LASD and LVM with risk of multiple health outcomes over long-term follow-up. These findings underscore the importance of maintaining optimal LASD and LVM values over the life course.
Study context
- Population
- Framingham participants with echocardiography-derived LASD and left ventricular mass (LVM), observations collected 1991 to 2008mean age 48 ± 13 years, 54.3% women
- Participants
- 8,192 participants
- Comparison
- Associations of echocardiography-derived LASD and LVM with risk of mortality, cardiovascular disease (CVD), dementia, hypertension, diabetes, and chronic kidney disease
Main finding
As reported in the abstract
Incident events · median follow-up 17 years
- deaths
- 1,245
- CVD
- 946
- dementia
- 290
- hypertension
- 1,565
- diabetes
- 463
- chronic kidney disease events
- 583
Further findings
| Outcome | HR (per-SD increase) (95% CI) | |
|---|---|---|
| HF with preserved ejection fraction — Higher LASD | 1.39 (1.06–1.84) | |
| HF with preserved ejection fraction — Higher LVM | 1.37 (1.08–1.74) | |
| HF with reduced ejection fraction | 2.13 (1.63–2.78) | |
| 0.20.5125Hazard ratio (log scale) |
All outcomes (LASD and LVM modeled separately)
- Higher LASD and LVM associated with higher risk of all outcomes, except for coronary heart disease
- all P < 0.05
- modeled separately
Death and CVD, including hard and atherosclerotic CVD (LASD and LVM modeled jointly)
- HR per-SD ranged from
- 1.18-1.28
- P
- all P < 0.001
- modeled jointly
Original publication
Associations of Left Atrial Dimension and Ventricular Mass With Long-Term Health Outcomes. JACC Adv. Published 11 March 2026. doi:10.1016/j.jacadv.2026.102643
Summarised from the published abstract; every number is checked against it