Arrhythmias & electrophysiology
Asymptomatic atrial fibrillation: Clinical characteristics, outcomes, and prognostic impact of rhythm control
Main finding · Composite CV death and strokeResult — go to the resultAdjusted hazard ratio 0.96 95% CI 0.81–1.14Authors' conclusion
Patients with asymptomatic AF had a comparable risk of adverse outcomes as symptomatic patients. Rhythm control was similarly beneficial regardless of symptoms.
Study context
- Population
- Patients with atrial fibrillation (AF) in the China-AF registryChina-AF registry
- Participants
- 15,603 patients
- Exposure
- Asymptomatic vs symptomatic AF; rhythm control by symptom status
- Asymptomaticn = 1,345
- Outcome
- Composite of:
- CV death
- Stroke
- Follow-up
- Median 5 years
Main finding
Composite:
Adjusted hazard ratio
0.96
95% CI 0.81–1.14
By group
Asymptomaticvs Symptomatic
aHR 0.96 (95% CI 0.81–1.14)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Composite outcome, rhythm control vs none, by symptom status (subgroup)
| aHR (95% CI) | ||
|---|---|---|
| Rhythm controlAsymptomatic | 0.37 (0.23–0.60) | |
| Rhythm controlSymptomatic | 0.55 (0.49–0.62) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Rhythm control use
- Asymptomatic proportion
- 8.6% · 1345
- Composite outcome, rhythm control vs none, by symptom status (subgroup): P for interaction = .111
Asymptomatic proportion
- Asymptomatic: higher proportion of males, nonparoxysmal AF, prolonged AF course and eccentric hypertrophy
Original publication
Asymptomatic atrial fibrillation: Clinical characteristics, outcomes, and prognostic impact of rhythm control. Heart Rhythm. Published 10 October 2025. doi:10.
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