Arrhythmias & electrophysiology
Insulin sensitivity, genetic predisposition, and risk of atrial fibrillation: A prospective cohort study
Authors' conclusion
eGDR demonstrates dose-dependent protective effects against AF across all genetic risk categories
Study context
- Population
- UK Biobank participants29,464 atrial fibrillation (AF) cases
- Participants
- 431,572 participants
- Exposure
- Higher vs lower estimated glucose disposal rate (eGDR), with AF polygenic risk score
- Outcome
- Incident AF
- Follow-up
- Median 13.53 years
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Each unit increase in eGDR9% reduction in AF risk
0.91(0.91–0.92)
P < 0.001Q4vs Q1
0.67(0.63–0.70)
P < 0.001- Higher eGDR quartiles: significantly lower AF incidence
- log-rank P < .001
- L-shaped nonlinear association
- P nonlinear < .001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident AF, by combined PRS and eGDRLow PRS and high eGDRvs High PRS and low eGDR74% lower AF risk | 0.26 (0.23–0.28) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Insulin sensitivity, genetic predisposition, and risk of atrial fibrillation: A prospective cohort study. Heart Rhythm. Published 10 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →