Arrhythmias & electrophysiology
Asymptomatic Patients With Brugada ECG Pattern: Long-Term Prognosis From a Large Prospective Study
Authors' conclusion
The entire population of asymptomatic patients with BrECG exhibits a relatively low event rate per year, which is important in view of the long life expectancy of these young patients. The presence of spontaneous type-1 BrECG associated with positive EPS identifies a subgroup at higher risk.
Study context
- Population
- Asymptomatic patients with Brugada ECG pattern (BrECG), 2 Italian centresfollow-up 2 to 22 years
- Participants
- 1,149 patients
- Exposure
- Spontaneous type-1 BrECG vs drug-induced-only type-1 BrECG
- Spontaneous type 1n = 539
- Drug-induced type 1n = 610reference
- Outcome
- Arrhythmic events (sudden death or documented VF or VT)
- Follow-up
- Median 6 (4-9) years
Methodological details2 Italian centres, consecutive patients
- 2 Italian centres
- Consecutive patients
Main finding
As reported in the abstract
Arrhythmic events · median 6 years
Spontaneous type 1
0.4% per year
16 of 539
Drug-induced type 1
0.03% per year
1 of 610
P < 0.001
- Overall asymptomatic population: 17 (1.5%) events
- 0.2% per year
Observational data: associations, not effects.
Further findings
Per year
| Outcome | Positive EPS | Negative EPS | Declined EPS | P value |
|---|---|---|---|---|
| Arrhythmic events by EPS result (spontaneous type 1)Positive EPS vs Negative EPS · 7 of 103 vs 4 of 236 | 0.7% | 0.2% | 0.4% | P = 0.025 |
- Arrhythmic events by electrophysiologic study (EPS) result (spontaneous type 1): EPS performed in 339 (63%) with spontaneous type 1; 200 declined EPS
Device-related death
- Device-related death
- 1
Original publication
Asymptomatic Patients With Brugada ECG Pattern: Long-Term Prognosis From a Large Prospective Study. Circulation. Published 13 October 2023. doi:10.
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