Arrhythmias & electrophysiology
The Safety and Feasibility of Pulsed-Field Ablation in Atrioventricular Nodal Re-Entrant Tachycardia: First-in-Human Pilot Trial
Authors' conclusion
PFA showed favorable feasibility and safety in patients with AVNRT in this pilot study.
Study context
- Population
- Patients with AVNRT diagnosed by electrophysiological examination, West China Hospital, Sichuan Universitymean age 47.9 ± 13.9 years
- Participants
- 30 patients
- Outcome
- Acute ablation success
Methodological detailsinvestigator-initiated, single-centre, pilot
- Investigator-initiated
- Single-centre
- Pilot
Main finding
As reported in the abstract
- Acute ablation success achieved in all patients
Observational data: associations, not effects.
Secondary outcomes
Sinus rhythm maintained · 6 months
- All patients maintained sinus rhythm after 6 months
Procedural characteristics
- Skin-to-skin procedure time, min (mean ± SD)
- 109.1 ± 32.1
- Fluoroscopy time, min (mean ± SD)
- 4.1 ± 0.9
- Pulsed-field ablation (PFA) applications, median (range)
- 8 (6.5 to 11.0)
- Distance of closest ablation site to His bundle, mm (average ± SD)
- 6.5 ± 2.5
- Minimum distance to His bundle, mm
- 2.0
Safety
| Outcome | Values |
|---|---|
| Adverse events · during ablation and 6-month follow-up | PFA 0 events |
Original publication
The Safety and Feasibility of Pulsed-Field Ablation in Atrioventricular Nodal Re-Entrant Tachycardia: First-in-Human Pilot Trial. JACC Clin Electrophysiol. Published 11 October 2023. doi:10.
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