Arrhythmias & electrophysiology
Atrial cardiomyopathy: markers and outcomes
Authors' conclusion
One in seven individuals had at least one marker of AtCM. Atrial cardiomyopathy markers were associated with AF, HF, and stroke, supporting AtCM as a common substrate for all three outcomes.
Study context
- Population
- UK Biobank individuals with CMR and ECG information4,145 (15.7%) with ≥1 marker
- Participants
- 26,467 individuals
- Exposure
- Atrial cardiomyopathy (AtCM) markers vs none
- ≥2 AtCM markersn = 619
- Outcome
- Incident AF, heart failure (HF) and stroke by AtCM markers
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
Incident AF
Each group vs no AtCM markerHazard ratio (95% CI)P value
1 AtCM marker
1.88(1.54–2.31)
P < 0.001≥2 AtCM markers
4.59(3.52–5.99)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| HF (≥2 AtCM markers)≥2 markersvs No AtCM marker | 3.08 (2.03–4.66) | P < 0.001 | |
| Stroke (≥2 AtCM markers)≥2 markersvs No AtCM marker | 3.07 (1.78–5.28) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Atrial fibrillation (AF) risk reclassification with AtCM markers
- Net reclassification improvement (NRI)
- 13.7% (95% CI: 9.2%-18.3%)
Risk factors for AtCM
- Age, CAD and hypertension consistently associated with AtCM
AF by AtCM markers plus clinical and genetic risk factors
- Additive effect on AF rates
Original publication
Atrial cardiomyopathy: markers and outcomes. Eur Heart J. Published 15 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →