Arrhythmias & electrophysiologyCohort study
Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1
- Prospective cohort study
- population-based
- meta-analysis of Atherosclerosis Risk in Communities (ARIC) and UK Biobank (UKB) cohorts
Authors' conclusion
Large TET2 and ASXL1, but not DNMT3A, CHIP was associated with higher IL-6 level, indices of cardiac remodeling, and increased risk for AF.
Study context
- Population
- Adults without hematologic malignancies, mitral valve stenosis or previous mitral valve procedure, ARIC and UK Biobank cohortsARIC 4131
- Participants
- 199,982 adults
- Exposure
- Clonal hematopoiesis of indeterminate potential (CHIP) vs no CHIP
- Large TET2 CHIPn = 1,340
- Large ASXL1 CHIPn = 314
- Outcome
- Incident atrial fibrillation (AF)
Main finding
As reported in the abstract
Each group vs no CHIPHazard ratio (95% CI)P value
Large CHIP
1.12(1.01–1.25)
P = 0.04Large TET2 CHIP
1.29(1.05–1.59)
P = 0.02Large ASXL1 CHIP
1.45(1.02–2.07)
P = 0.04Observational data: associations, not effects.
Further findings
Biomarkers and cardiac structure
- Large TET2 CHIP associated with higher IL-6 levels
- Large ASXL1 associated with higher hs-TnT level and increased LV mass index
Original publication
Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1. JAMA Cardiol. Published 1 June 2024. doi:10.1001/jamacardio.2024.0459
Summarised from the published abstract; every number is checked against it