Heart failure & cardiomyopathies
Atrial Fibrillation/Flutter in Transthyretin Cardiac Amyloidosis: Prevalence, Incidence, Clinical Predictors, and Effect of Tafamidis
Authors' conclusion
More than half of the ATTR-CA patients have AF, which was associated with wild-type amyloid transthyretin, greater Columbia stage, and increased LAVI. About half of the ATTR-CA individuals developed AF after 2 years, which was predicted by the Columbia score, but not the CHARGE-AF score. ATTRv and tafamidis were protective against incident AF.
Study context
- Population
- Patients with transthyretin cardiac amyloidosis (ATTR-CA)
- Participants
- 419 patients
- Outcome
- Predictors of prevalent and incident AF (atrial fibrillation/flutter), and effect of tafamidis
Main finding
As reported in the abstract
baseline
Odds ratio (95% CI)P value
Higher Columbia scoreprevalent AF
1.48(1.25–1.75)
P < 0.05Higher LAVIprevalent AF
1.05(1.02–1.08)
P < 0.05ATTRvprevalent AF; protective
0.19(0.07–0.55)
P < 0.05- Atrial fibrillation/flutter (AF) present at baseline
- 58% (n = 244)
Observational data: associations, not effects.
Further findings
Incident AF in patients without prior AF (Cox regression) · median follow-up 2 years
| HR (95% CI) | P value | ||
|---|---|---|---|
| Higher Columbia scoreNew onset AF | 1.18 (1.01–1.38) | P = 0.035 | |
| ATTRvProtective | 0.44 (0.23–0.87) | P = 0.017 | |
| TafamidisProtective | 0.54 (0.30–0.95) | P = 0.034 | |
| 0.20.5125Hazard ratio (log scale) |
- Incident AF in patients without prior AF (Cox regression) — Incident AF in subjects without prior AF
- 71 (41%)
Incident AF in patients without prior AF (Cox regression) · median follow-up 2 years
- CHARGE-AF and left atrial volume index (LAVI) not associated with new onset AF
Original publication
Atrial Fibrillation/Flutter in Transthyretin Cardiac Amyloidosis: Prevalence, Incidence, Clinical Predictors, and Effect of Tafamidis. JACC Adv. Published 24 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →