Heart failure & cardiomyopathies
Prognostic Value of CMR-Derived Left Ventricular Filling Pressure in Broad Referral Populations
Main finding · Primary outcome (HF hospitalization, transplantation or LV assist device)Result — go to the resultSubdistribution hazard ratio 1.988 95% CI 1.659–2.381Authors' conclusion
LVFPcmr is a powerful predictor of future HF outcomes in broad referral populations inclusive of patients with reduced, mildly reduced, and preserved LV function.
Study context
- Population
- Broad cardiovascular magnetic resonance (CMR) referral population, Calgary registry, 2015–2021
- Participants
- 9,588 participants
- Exposure
- Higher vs lower CMR-derived left ventricular (LV) filling pressure
- Outcome
- Primary outcome
- Follow-up
- Median 6.4 years
Methodological detailsconsecutively enrolled, Cardiovascular Imaging Registry of Calgary
- Consecutively enrolled
- Cardiovascular Imaging Registry of Calgary
Main finding
As reported in the abstract
Primary outcome:
- Heart failure (HF) hospitalization
- Transplantation
- LV assist device
Subdistribution hazard ratio
1.988
95% CI 1.659–2.381
P < 0.001
Q3vs Q1
subdistribution HR 1.988 (95% CI 1.659–2.381); P < 0.001
- Patients with primary outcome
- 1,142 (12%)
Observational data: associations, not effects.
Further findings
Primary outcome with LVFPcmr ≥18 mm Hg, by LVEF subgroup
- Adjusted HR, LVEF <40%
- 1.510 (1.216-1.876)
- Adjusted HR, LVEF 40 to 50%
- 1.582 (1.153-2.171)
- Adjusted HR, LVEF >50%
- 2.865 (2.307-3.559)
- LVEF >50%: similar value in patients with vs without coronary disease
- Optimal cutpoint 18 mm Hg (survival-based approach)
Original publication
Prognostic Value of CMR-Derived Left Ventricular Filling Pressure in Broad Referral Populations. JACC Adv. Published 24 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →