Valvular & structural heart disease
Atrial Fibrillation in Valvular Heart Disease: Assessing the Impact of Genetics in the UK Biobank
Authors' conclusion
In VHD, AF PRS predicts AF risk, but the genetic impact differs by subtype. AV disease shows minimal genetic contribution, suggesting predominantly hemodynamic risk, while MV disease-particularly MVP-shows substantial genetic influence.
Study context
- Population
- UK Biobank participants with available atrial fibrillation (AF) polygenic risk score, with valvular heart disease subtypesparticipants with available polygenic risk score (PRS) · MVP 385 · mitral regurgitation 1,058 · mitral stenosis 81 · aortic regurgitation 421 · aortic stenosis 509
- Participants
- 452,841 participants
- Exposure
- AF PRS categories and incident AF across valvular heart disease (VHD) subtypes
- Outcome
- Incident AF in MV disease
Main finding
As reported in the abstract
Hazard ratio
1.7
P = 0.03
intermediate PRS
Hazard ratio
2.3
P = 0.002
high PRS
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| Incident AF in MVPStrongest effect | 3.1 | P = 0.03 |
Incident AF in aortic valve (AV) disease
- PRS not significantly associated with AF risk, intermediate PRS
- P = 0.93
- PRS not significantly associated with AF risk, high PRS
- P = 0.07
Interaction analyses
- Attenuation or absence of PRS effect in AV disease, intermediate PRS
- P = 0.04
- Attenuation or absence of PRS effect in AV disease, high PRS
- P = 0.004
- No significant interaction in mitral valve (MV) disease, intermediate PRS
- P = 0.80
- No significant interaction in MV disease, high PRS
- P = 0.11
Original publication
Atrial Fibrillation in Valvular Heart Disease: Assessing the Impact of Genetics in the UK Biobank. JACC Adv. Published 20 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it