Arrhythmias & electrophysiology
Atrial fibrillation substrate and impaired left atrial function: a cardiac MRI study
Authors' conclusion
LA fibrosis, a major component of the AF substrate, and EAT, an important contributor, are associated with a worsening LA function through strain analysis by CMR.
Study context
- Population
- Patients with atrial fibrillation (AF) undergoing pre-ablation cardiac magnetic resonance (CMR) (39% female, average age 62 years)
- Participants
- 101 patients
- Outcome
- Association of LA fibrosis and LA EAT with LA strain (GLRS, GLCdS, GLCtS) and function by CMR
Main finding
As reported in the abstract
Correlations of LA fibrosis and LA EAT with LA strain and function
- LA fibrosis vs GLRS
- R = −0.35, P < 0.001
- LA fibrosis vs GLCdS
- R = −0.24, P = 0.015
- LA fibrosis vs GLCtS
- R = −0.2, P = 0.046
- Posterior wall fibrosis vs GLRS
- R = −0.32, P = 0.001
- Lateral wall fibrosis vs GLRS
- R = −0.33, P = 0.001
- LA epicardial adipose tissue (EAT) vs GLCdS
- R = −0.453, P < 0.001
- LA fibrosis vs LA emptying fraction
- R = −0.27, P = 0.007
- LA EAT vs LA emptying fraction (not correlated)
- R = −0.22, P = 0.1
- LA EAT vs LA volume
- R = 0.38, P = 0.003
- LA fibrosis vs LA volume
- R = 0.24, P = 0.016
Observational data: associations, not effects.
Original publication
Atrial fibrillation substrate and impaired left atrial function: a cardiac MRI study. Europace. Published 11 November 2024. doi:10.
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