Arrhythmias & electrophysiology
Atrial flutter and sick sinus syndrome
Authors' conclusion
AFL is associated with an increased risk of incident SSS and its adverse consequences, especially in patients with coexisting AF.
Study context
- Population
- Adults aged ≥18 years receiving hospital-based care in California, 2005–201954% female
- Participants
- 29,357,609 adults
- Exposure
- Atrial flutter (AFL) and/or AF vs neither arrhythmia
- AFL alonen = 101,243
- AF alonen = 1,674,680
- AF and AFLn = 284,547
- Outcome
- Incident SSS and associated syncope and PPM implantation
Methodological detailsCox proportional hazards models adjusted for demographics and comorbidities
- Cox proportional hazards models adjusted for demographics and comorbidities
Main finding
As reported in the abstract
SSS, associated syncope and PPM implantation
AF and AFL vs AF aloneHazard ratio (95% CI)
SSS
1.62(1.59–1.64)
Syncope
1.63(1.54–1.72)
PPM implantation
1.74(1.70–1.79)
- AF, AFL and both arrhythmias each associated with increased risk of sick sinus syndrome (SSS), syncope and permanent pacemaker (PPM) implantation (adjusted)
- all P < .001
Observational data: associations, not effects.
Original publication
Atrial flutter and sick sinus syndrome. Heart Rhythm. Published 22 October 2024. doi:10.
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