Arrhythmias & electrophysiology

Incidence, management, and prognostic impact of arrhythmias in patients with Takotsubo syndrome: a nationwide retrospective cohort study

Eur Heart J Acute Cardiovasc CarePublished Retrospective cohort study

Authors' conclusion

Arrhythmias are not uncommon in TTS. Patients' background characteristics, rather than arrhythmia itself, may be associated with in-hospital mortality.

Study context

Population
Patients hospitalised for Takotsubo syndrome, Japanese Diagnosis Procedure Combination database, July 2010–March 2021
Participants
16,713 patients
Exposure
Serious arrhythmias vs no serious arrhythmias
  • Arrhythmian = 1,036
Outcome
Incidence of serious arrhythmias
Methodological detailsnationwide
  • Nationwide

Main finding

As reported in the abstract

GroupValueVT/VF2nd-/3rd-degree atrioventricular block (AVB)Sick sinus syndrome (SSS)Multiple arrhythmiasOthers
Arrhythmia6.2%44928313355116

Arrhythmia

Value6.2%
VT/VF449
2nd-/3rd-degree atrioventricular block (AVB)283
Sick sinus syndrome (SSS)133
Multiple arrhythmias55
Others116

Observational data: associations, not effects.

Further findings

In-hospital mortality · crude

P < 0.001

OutcomeOR (95% CI)
In-hospital mortalityAdjusted for confounders1.15 (0.90–1.49)
Device implantation (arrhythmia group)
24.5% · 254 of 1036

In-hospital mortality

Age, sex, ADLs, consciousness level and Charlson comorbidity index significantly associated with mortality

Original publication

Incidence, management, and prognostic impact of arrhythmias in patients with Takotsubo syndrome: a nationwide retrospective cohort study. Eur Heart J Acute Cardiovasc Care. Published 15 September 2023. doi:10.1093/ehjacc/zuad110

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