Arrhythmias & electrophysiology
Incidence, management, and prognostic impact of arrhythmias in patients with Takotsubo syndrome: a nationwide retrospective cohort study
Authors' conclusion
Arrhythmias are not uncommon in TTS. Patients' background characteristics, rather than arrhythmia itself, may be associated with in-hospital mortality.
Study context
- Population
- Patients hospitalised for Takotsubo syndrome, Japanese Diagnosis Procedure Combination database, July 2010–March 2021
- Participants
- 16,713 patients
- Exposure
- Serious arrhythmias vs no serious arrhythmias
- Arrhythmian = 1,036
- Outcome
- Incidence of serious arrhythmias
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
| Group | Value | VT/VF | 2nd-/3rd-degree atrioventricular block (AVB) | Sick sinus syndrome (SSS) | Multiple arrhythmias | Others |
|---|---|---|---|---|---|---|
| Arrhythmia | 6.2% | 449 | 283 | 133 | 55 | 116 |
Arrhythmia
Value6.2%
VT/VF449
2nd-/3rd-degree atrioventricular block (AVB)283
Sick sinus syndrome (SSS)133
Multiple arrhythmias55
Others116
Observational data: associations, not effects.
Further findings
In-hospital mortality · crude
P < 0.001
| Outcome | OR (95% CI) | |
|---|---|---|
| In-hospital mortalityAdjusted for confounders | 1.15 (0.90–1.49) | |
| 0.512Odds ratio (log scale) |
- Device implantation (arrhythmia group)
- 24.5% · 254 of 1036
In-hospital mortality
- Age, sex, ADLs, consciousness level and Charlson comorbidity index significantly associated with mortality
Original publication
Incidence, management, and prognostic impact of arrhythmias in patients with Takotsubo syndrome: a nationwide retrospective cohort study. Eur Heart J Acute Cardiovasc Care. Published 15 September 2023. doi:10. 1093/ ehjacc/ zuad110
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