Valvular & structural heart disease
Atrial-Secondary Tricuspid Regurgitation: A Better Prognosis in Early Stage Heart Failure, But Not in Late Stage
Authors' conclusion
Though A-STR carries a more favourable prognosis in mildly symptomatic patients, this distinction is irrelevant in patients with advanced disease.
Study context
- Population
- Patients with severe secondary tricuspid regurgitation, 16 French hospitals, 2017–201925 could not be classified
- Participants
- 281 patients
- Exposure
- A-STR vs mixed/V-STR, stratified by New York Heart Association (NYHA) class
- A-STRn = 91
- Mixed/V-STRn = 164reference
- Outcome
- Time to CVD-related hospitalization or death, whichever came first
Methodological details16 French hospitals
- 16 French hospitals
Main finding
As reported in the abstract
Event-free survival, by NYHA class (stratified analysis) · estimated 5 year
NYHA I-II
P < 0.05
NYHA III-IV
P > 0.05
Observational data: associations, not effects.
Further findings
Event-free survival, all patients (confounded by NYHA class, P = 0.0104)
- No differences in event-free survival among groups (70.7% vs. 65.9%)
- P = 0.59
- Confounded by NYHA class (P = 0.0104)
Original publication
Atrial-Secondary Tricuspid Regurgitation: A Better Prognosis in Early Stage Heart Failure, But Not in Late Stage. ESC Heart Fail. Published 9 July 2025. doi:10.
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