Arrhythmias & electrophysiology

Atrial Topology for a Unified Understanding of Typical and Atypical Flutter

Circ Arrhythm ElectrophysiolPublished Translational study

Authors' conclusion

Combining topology with the index theorem offers a novel and cohesive framework for understanding and managing typical and atypical flutter.

Study context

Population
Cases of typical and atypical flutter (macroreentrant atrial tachycardia)106 left atrium, 25 right atrium
Participants
131 cases
Outcome
Topological features of macroreentrant atrial tachycardia (modelling) and explanation of clinical activation, entrainment and ablation responses
Methodological detailscomputational spherical mesh model, clinical database
  • Computational spherical mesh model
  • Clinical database

Main finding

As reported in the abstract

  • Reentry on closed surfaces consistently manifests as paired rotation
  • An odd number of critical boundaries is mathematically impossible
  • Unifying construct (with index theorem) explained number of loops, PPI-TCL values and ablation outcomes (termination, no change or TCL prolongation) in all 131 cases

Original publication

Atrial Topology for a Unified Understanding of Typical and Atypical Flutter. Circ Arrhythm Electrophysiol. Published 5 November 2024. doi:10.1161/circep.124.013102

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