Arrhythmias & electrophysiology
Shared genetic associations and aetiology between obstructive sleep apnoea and cardiovascular diseases: a genome-wide cross-trait analysis and bidirectional Mendelian randomization analysis
Authors' conclusion
Our study suggests strong genetic correlations between OSA and several CVDs.
Study context
- Population
- Genome-wide association study (GWAS) data on obstructive sleep apnoea (OSA) and cardiovascular diseases (CVDs) (coronary artery disease (CAD), heart failure (HF), myocardial infarction (MI), stroke, atrial fibrillation (AF))
- Outcome
- Genetic correlations and potential causal relationships between OSA and CVDs
Methodological detailsGWAS data, linkage disequilibrium score regression, multi-trait analysis of GWAS (MTAG), Bayesian co-localization, latent causal variable analysis
- GWAS data
- Linkage disequilibrium score regression
- MTAG
- Bayesian co-localization
- Latent causal variable analysis
Main finding
As reported in the abstract
Shared loci between OSA and CAD (cross-trait MTAG)
15
Shared loci between OSA and MI (cross-trait MTAG)
25
Shared loci between OSA and HF (cross-trait MTAG)
7
Further findings
Latent causal variable analysis
- AF causally associated with OSA; HF showed partial causality
Tissue expression of shared genes
- Primarily expressed in blood, heart, kidney, liver, muscle and pancreas
Original publication
Shared genetic associations and aetiology between obstructive sleep apnoea and cardiovascular diseases: a genome-wide cross-trait analysis and bidirectional Mendelian randomization analysis. Eur J Prev Cardiol. Published 5 November 2024. doi:10.
Summarised from the published abstract; every number is checked against it