LidocAine Versus Opioids In MyocarDial infarction: the AVOID-2 randomized controlled trial
Primary result · Prehospital pain reduction (NRS)Result — go to the resultEstimated median difference −1 95% CI −1.58 to −0.42Authors' conclusion
IV Lidocaine did not meet the criteria for non-inferiority with lower prehospital pain reduction than fentanyl but was safe and better tolerated as analgesia in ST-elevation myocardial infarction (STEMI).
Study context
- Population
- Patients with suspected STEACS with moderate to severe pain (numerical rating scale (NRS) ≥5/10)
- Participants
- 308 patients
- Comparison
- IV lidocaine vs IV fentanyl for prehospital analgesia
- Primary endpoint
- Co-primary: prehospital pain reduction and adverse events requiring intervention
Methodological detailsPhase II, prehospital, open-label, non-inferiority
- Phase II
- Prehospital
- Open-label
- Non-inferiority
Primary result
Prehospital pain reduction (NRS)
Estimated median difference
−1
95% CI −1.58 to −0.42
P = 0.5 for non-inferiority
Change by group
Fentanyl
4
median
Lidocaine
3
median
Lidocainevs Fentanyl
estimated median difference −1 (95% CI −1.58 to −0.42); P = 0.5 for non-inferiority
As reported in the abstract
Secondary outcomes
Myocardial infarct size (cardiac MRI (cMRI)) and clinical outcomes · 30 days
- No significant differences in myocardial infarct size and clinical outcomes
Safety
Adverse events requiring intervention (co-primary) · for superiority · met non-inferiority and superiority favouring lidocaine
P = 0.016
Original publication
LidocAine Versus Opioids In MyocarDial infarction: the AVOID-2 randomized controlled trial. Eur Heart J Acute Cardiovasc Care. Published 10 December 2022. doi:10.
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