Balancing the risk of major bleeding against vascular disease risk in people without atherosclerotic disease
Authors' conclusion
The derived models using routinely available disease history and laboratory measurements improved distinction of the MVE-to-MB ratio compared with using conventional models for MB risk including vascular risk factors. Such models can help identify those with moderate MVE risk but low MB risk who may benefit from low-dose aspirin.
Study context
- Population
- UK Biobank participants without known atherosclerotic cardiovascular disease at baseline
- Participants
- 431,167 UK Biobank participants
- Exposure
- Ratios of observed MVE-to-MB rates across risk categories
- Outcome
- Incident MVE and MB
- Follow-up
- Median 12 years
Methodological detailsrecord linkage, cross-validated risk scores, Cox proportional hazards models
- Record linkage
- Cross-validated risk scores
- Cox proportional hazards models
Main finding
As reported in the abstract
median follow-up of 12 years
Participants with an MVE
18 310
Participants with an major bleeding (MB)
5352
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| MB risk4.3-fold difference in risk | 4.3 (3.87–4.77) | |
| 0.20.5125Hazard ratio (log scale) |
MB risk
- MB risk highest among participants with frailty, prior bleeds, cancer, liver disease or renal dysfunction
MVE-to-MB ratio
- Highest MB risk groups
- =2.6
- Lower MB risk categories
- =4
Original publication
Balancing the risk of major bleeding against vascular disease risk in people without atherosclerotic disease. Heart. Published 26 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →