Bariatric Surgery Improves Cardiac Remodeling and Function in Adults With Preserved Left Ventricular Ejection Fraction
Authors' conclusion
Bariatric surgery may be an effective and safe way to prevent and/or reverse obesity-related cardiac abnormalities. Larger prospective studies are warranted to confirm these observations and determine their long-term clinical implications.
Study context
- Population
- Adults with severe obesity (body mass index ≥35 kg/m²) and preserved left ventricular (LV) ejection fraction (≥50%)
- Exposure
- Bariatric surgery vs obesity managed medically
- Bariatric surgeryn = Thirty-eight
- Obesity managed medicallyn = 34
- Outcome
- Baseline characteristics
- Follow-up
- Baseline
Main finding
As reported in the abstract
Mean age
48.5 ± 8.3 years
Female
75%
Body mass index
46.4 ± 3.7 kg/m²
Observational data: associations, not effects.
Further findings
- Percentage of total weight loss · 12-month follow-up — Bariatric surgery
- 36.7% ± 7.1%
- Worsened subclinical systolic function, obesity managed medically · during the follow-up
- 38%
- Worsened subclinical systolic function, obesity managed medically — P
- P < 0.05
LV mass and LV hypertrophy · 12-month follow-up
- Significant reduction in LV mass and LV hypertrophy with bariatric surgery
- P < 0.001
LV diastolic function parameters · 12-month follow-up
- Improvement in LV diastolic function parameters with bariatric surgery
- P < 0.01
LV global longitudinal strain · 12-month follow-up
- Bariatric surgery, LV global longitudinal strain
- 16.3% ± 2.5% vs 18.5% ± 1.3%
- P
- P < 0.05
Subclinical cardiac function abnormalities
- Preoperative abnormalities of subclinical cardiac function prevalent
- 79%
- Normalized after surgery
- 70% of subjects
Original publication
Bariatric Surgery Improves Cardiac Remodeling and Function in Adults With Preserved Left Ventricular Ejection Fraction. JACC Adv. Published August 2026. doi:10.
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