Heart failure & cardiomyopathies
Baroreflex Activation Therapy in Patients with Heart Failure with Reduced Ejection Fraction: A Single-Centre Experience
Authors' conclusion
Patients with HFrEF who are selected for BAT are in a stage of worsening or even advanced heart failure. BAT appears to be safe and improves clinical symptoms and-to a modest degree-left ventricular function. The risk of death remains high in advanced disease stages.
Study context
- Population
- Heart failure with reduced ejection fraction (HFrEF), New York Heart Association (NYHA) III–IV, left ventricular ejection fraction (LVEF) <35% despite guideline-directed medical therapy, 2014–2020
- Participants
- 30 participants
- Outcome
- NYHA class, LVEF and NT-proBNP from baseline to 12 months
- Follow-up
- 12 months
Methodological detailsnon-randomized, single-centre, Device implantation successful in all patients
- Non-randomized
- Single-centre
- Device implantation successful in all patients
Main finding
As reported in the abstract
- NYHA class improved in 19 patients, unchanged in 5 (baseline III/IV: 26 (87%)/4 (13%))
- P < 0.001
- LVEF, median (IQR): 25.5 (20.0-30.5) % at baseline vs 30.0 (25.0-36.0) % at 12 months
- P = 0.014
- N-terminal prohormone of brain natriuretic peptide (NT-proBNP), median (IQR): 3165 (880-8085) vs 1001 (599-3820) pg/mL, numerical decrease not significant
- P = 0.526
Observational data: associations, not effects.
Further findings
Mortality · 1 and 3 years
- Mortality at 1 year
- n = 6, 20%
- Mortality at 3 years
- n = 10, 33%
- As expected by MAGGIC risk score
- NYHA class and estimated glomerular filtration rate (eGFR) independent predictors of mortality
- Median follow-up 16 (10-33) months
Clinical events by baseline status
- Event rate high with NYHA IV, NT-proBNP >1600 pg/mL or eGFR <30 mL/min at baseline
Original publication
Baroreflex Activation Therapy in Patients with Heart Failure with Reduced Ejection Fraction: A Single-Centre Experience. ESC Heart Fail. Published 4 September 2023. doi:10.
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