Heart failure & cardiomyopathies
Baseline characteristics in the TransitionCHF study: asymptomatic patients with heart failure and reduced ejection fraction
Authors' conclusion
Patients included in the TransitionCHF study are younger and suffer from fewer comorbidities as compared with symptomatic heart failure patients. Associations between NT-proBNP levels and markers of exercise performance were weak.
Study context
- Population
- Patients with asymptomatic systolic left ventricular dysfunction (ASLVD), New York Heart Association (NYHA) I, ejection fraction ≤ 40%individuals with ASLVD NYHA I recruited
- Participants
- 1,005 patients
- Exposure
- Patient characteristics compared with other studies involving patients with symptomatic heart failure
- Outcome
- Baseline characteristics
Main finding
As reported in the abstract
Mean age
60 ± 14 years
Women
18%
Mean ejection fraction
36%
Mean left ventricular end-diastolic diameter
59 mm
Observational data: associations, not effects.
Further findings
Comparison with studies of symptomatic heart failure
- Age younger
- ≈ 5 years
- Frequency of comorbidities lower
Correlations of SF-36 physical functioning score
- MQ (moderate)
- r = −0.44
- 6-min walking distance (weak)
- r = 0.32
- Peak VO2 at ergospirometry (weak)
- r = 0.28
- HAF17 (weak)
- r = −0.34
Correlations of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels
- Peak VO2 (weak)
- r = −0.29
- 6-min walk distance (weak)
- r = −0.21
Original publication
Baseline characteristics in the TransitionCHF study: asymptomatic patients with heart failure and reduced ejection fraction. ESC Heart Fail. Published 21 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →