Heart failure & cardiomyopathies
Baseline Characteristics of Pediatric Patients With Heart Failure Due to Systemic Left Ventricular Systolic Dysfunction in the PANORAMA-HF Trial
Authors' conclusion
Compared to other pediatric HF studies, PANORAMA-HF recruited a relatively homogeneous pediatric HF population across 3 age groups, enabling a more robust evaluation of pharmacokinetics/pharmacodynamics and efficacy/safety of sacubitril/valsartan. Most patients had mildly symptomatic HF at baseline.
Study context
- Population
- Pediatric patients with heart failure (HF) due to LV systolic dysfunction with biventricular physiologyrandomised
- Participants
- 375 patients
- Comparison
- Sacubitril/valsartan vs enalapril
Methodological detailsmulticentre, Phase II/III, adaptive, seamless, 2-part design
- Multicentre
- Phase II/III
- Adaptive, seamless, 2-part design
Primary result
As reported in the abstract
Baseline characteristics
- Prior HF hospitalization
- About 70%
- NYHA/Ross class I/II HF
- 85%
- ACEi/ARB naïve
- ≈8%
Original publication
Baseline Characteristics of Pediatric Patients With Heart Failure Due to Systemic Left Ventricular Systolic Dysfunction in the PANORAMA-HF Trial. Circ Heart Fail. Published 5 January 2023. doi:10.
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