Aortic & peripheral vascular disease
Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2/3–MAPK Signaling to Trigger Spontaneous Aortic Dissection
Authors' conclusion
These findings unveil a critical role of Best3 in regulating smooth muscle cell phenotypic switch and aortic structural integrity through controlling MEKK2/3 degradation.
Study context
- Population
- Mice; human aortic dissection (AD) aortic samples and single-cell transcriptome data
- Comparison
- Best3SMKO and Best3ECKO mice
- Outcome
- Spontaneous AD and mechanism
Methodological detailssmooth muscle cell-specific and endothelial cell-specific knockout mice
- Smooth muscle cell-specific and endothelial cell-specific knockout mice
Main finding
As reported in the abstract
| Group | Value | AD incidence at 72 weeks of age |
|---|---|---|
| Best3SMKO | 48% | 48% |
Best3SMKO
Value48%
AD incidence at 72 weeks of age48%
Original publication
Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2/3–MAPK Signaling to Trigger Spontaneous Aortic Dissection. Circulation. Published 19 May 2023. doi:10.
Summarised from the published abstract; every number is checked against it