Heart failure & cardiomyopathies
Bioimpedance Analysis Predicts Worsening Events in Outpatients with Heart Failure and Reduced Ejection Fraction
Authors' conclusion
VO assessed by BIA is independently associated with WHF in stable outpatients with HFrEF at 3 months.
Study context
- Population
- Consecutive stable heart failure (HF) outpatients with left ventricle ejection fraction (LVEF) below 40% (HFrEF)
- Participants
- 100 outpatients
- Outcome
- WHF (ED visits for HF or hospitalization for HF)
- Follow-up
- 3 months
Methodological detailssingle-centre, observational, volume overload (VO) = measured weight minus bioelectrical impedance analysis (BIA)-assessed dry weight
- Single-centre
- Observational
- VO = measured weight minus BIA-assessed dry weight
Main finding
As reported in the abstract
WHF predicted by VO assessed by BIA
- Patients meeting primary endpoint
- 11
- Median VO (IQR 0-1.6 L)
- 0.5 L
- VO only independent predictor of worsening heart failure (WHF), multivariate logistic regression: adjusted OR
- 2.7 (95% CI 1.30-5.63, P = 0.008)
- VO, multivariate Cox regression: adjusted HR
- 2.03 (95% CI 1.37-3.02, P < 0.001)
- VO, ROC AUC
- 0.88 (95% CI 0.79-0.97, P < 0.001)
- Optimal VO cut-off
- 1.2 L
Observational data: associations, not effects.
Further findings
Univariate predictors of WHF
- E/e', NT-proBNP, IVC dilatation (≥21 mm), signs of congestion and VO associated with primary endpoint (univariate)
Original publication
Bioimpedance Analysis Predicts Worsening Events in Outpatients with Heart Failure and Reduced Ejection Fraction. ESC Heart Fail. Published 23 July 2024. doi:10.
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