Heart failure & cardiomyopathies
Immune Cell Profiling of the ICAM1 p.K56M Heart Failure with Preserved Ejection Fraction Risk Variant
Authors' conclusion
The ICAM1 p.K56M variant (rs5491) carries a distinct and inflammatory T-cell subset profile. These cytotoxic T cells are in turn associated with alterations in cardiac function and adverse haemodynamics later in life, thus providing insight into pathways by which rs5491 may increase the risk of HFpEF.
Study context
- Population
- African American individuals in the Multi-Ethnic Study of Atherosclerosis with immune cell profilingmean age 63 years, 51% female
- Participants
- 502 individuals
- Exposure
- ICAM1 rs5491 carriers vs non-carriers
- Outcome
- Associations of rs5491 with 29 circulating peripheral blood mononuclear cell subsets
Methodological detailscross-sectional analysis within the Multi-Ethnic Study of Atherosclerosis
- Cross-sectional analysis within the Multi-Ethnic Study of Atherosclerosis
Main finding
As reported in the abstract
Circulating immune cell subsets, per additional rs5491 allele
- Tc17 CD8+ cytotoxic T cells: higher proportion (β = 1.34, SE = 0.45)
- P = 9.5 × 10-5
- Tc2 CD8+ cytotoxic T cells: higher proportion (β = 1.19, SE = 0.44)
- P = 0.00012
Observational data: associations, not effects.
Further findings
Top immune cells vs echocardiographic structure and function
- Higher Tc17 proportion significantly associated with higher LVEF, E/e' average and RV systolic pressure (right ventricular systolic pressure (RVSP))
- Higher Tc2 proportion significantly associated with higher RVSP
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Immune Cell Profiling of the ICAM1 p.K56M Heart Failure with Preserved Ejection Fraction Risk Variant. ESC Heart Fail. Published 22 July 2024. doi:10.
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