Blood pressure and cardiovascular outcomes in patients with diabetes and high cardiovascular risk
Authors' conclusion
In patients with diabetes and elevated CV risk, even after extensive adjustment for underlying disease burden, there was a persistent association for low DBP with subclinical myocardial injury and risk of MI.
Study context
- Population
- Patients with T2DM and elevated cardiovascular (CV) riskbiomarker subgroup
- Participants
- 12,175 patients
- Comparison
- Baseline BP strata
- Primary endpoint
- Composite of:
- CV death
- MI
- Ischaemic stroke
Methodological detailsbiomarker subgroup, stratified by baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP), adjusted for clinical covariates, NT-proBNP and high-sensitivity troponin-T (hsTnT)
- Biomarker subgroup
- Stratified by baseline SBP and DBP
- Adjusted for clinical covariates, NT-proBNP and hsTnT
Primary result
As reported in the abstract
CV death, MI or ischaemic stroke by baseline SBP and DBP
U-shaped relationship of adjusted risk with baseline SBP and DBP
Pquadratic ≤ 0.01
Nadir SBP
130-140 mmHg
Nadir DBP
80-90 mmHg
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| MI | 2.30 (1.50–3.53) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
hsTnT ≥14 ng/L
- U-shaped relationship of adjusted odds with SBP and DBP
- Pquadratic ≤ 0.01
Low DBP, elevated hsTnT and myocardial infarction (MI) excluding prior HF or NT-proBNP >median
- Relationships remained
Original publication
Blood pressure and cardiovascular outcomes in patients with diabetes and high cardiovascular risk. Eur Heart J. Published 31 January 2018. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →