High-Target Versus Low-Target Blood Pressure Management During Cardiopulmonary Bypass to Prevent Cerebral Injury in Cardiac Surgery Patients: A Randomized Controlled Trial
Primary result · Volume of new cerebral lesionsResult — go to the resultMedian difference 0 95% CI −25 to 0.028Authors' conclusion
Among patients undergoing on-pump cardiac surgery, targeting a higher versus a lower mean arterial pressure during cardiopulmonary bypass did not seem to affect the volume or number of new cerebral infarcts.
Study context
- Population
- Patients undergoing on-pump cardiac surgery with cardiopulmonary bypass
- Participants
- 197 patients
- Comparison
- High-target vs low-target MAP during cardiopulmonary bypass
- High-targetn = 98
- Low-targetn = 99reference
- Primary endpoint
- Total volume of new ischemic cerebral lesions on diffusion-weighted MRI (pre- vs postoperative)
- Follow-up
- Postoperatively between days 3 and 6
Methodological detailspatient- and assessor-blinded
- Patient- and assessor-blinded
Primary result
Volume of new cerebral lesions
Median difference
0
95% CI −25 to 0.028
P = 0.99
By group
High-targetvs Low-target
median difference 0 (95% CI −25 to 0.028); P = 0.99
As reported in the abstract
Secondary outcomes
| Outcome | High-target | Low-target | Median difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Number of new lesions | 1 (IQR 0–2) | 1 (IQR 0–2) | 0 (0–0) | P = 0.71 | |
| Range | 0-29 | 0-24 | |||
| 0000000Difference (linear scale) |
Patients with new cerebral lesions
P = 0.76
Safety
- No significant difference in frequency of severe adverse events
Original publication
High-Target Versus Low-Target Blood Pressure Management During Cardiopulmonary Bypass to Prevent Cerebral Injury in Cardiac Surgery Patients: A Randomized Controlled Trial. Circulation. Published 16 January 2018. doi:10.
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