Blood pressure changes during smoking cessation in a randomized, double-blind, placebo-controlled trial of dulaglutide treatment
Authors' conclusion
Our analysis suggests that smoking cessation may have a beneficial effect on blood pressure- especially in hypertensive individuals-, counteracting the expected blood pressure increase caused by post-cessation weight gain.
Study context
- Population
- Smokers undergoing a 12-week smoking cessation programme, followed for 52 weeks218 analysed
- Participants
- 255 smokers
- Comparison
- Abstinent vs smoking individuals; dulaglutide vs placebo
- Primary endpoint
- Change in SBP in abstinent vs smoking individuals
- Follow-up
- 52 weeks
Methodological detailspredefined secondary analysis, double-blind, placebo-controlled
- Predefined secondary analysis
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Change in SBP
Weight gain at Week 52
+3 kg
0, 5.4
Further findings
SBP change, subgroup with minimal weight gain ≤3 kg
- BP reduction
- −4.6 mmHg (−9, 3)
SBP change, subgroup with hypertensive BP at baseline
- BP reduction
- −16 mmHg (−22, 2)
BP with dulaglutide · Week 52
- Initial reduction in body weight and BP, then weight rebound and BP increase
- +7.5 mmHg (−1, 15)
Path analysis
- Weight identified as an important factor influencing BP during smoking cessation
Original publication
Blood pressure changes during smoking cessation in a randomized, double-blind, placebo-controlled trial of dulaglutide treatment. Eur J Prev Cardiol. Published 3 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it