Arrhythmias & electrophysiology

Body Fat Distribution and Left Atrial Reverse Remodeling After Catheter Ablation for Atrial Fibrillation

JACC AdvPublished Cohort study

Authors' conclusion

Central adiposity was associated with a lack of LARR after CA

Study context

Population
Nonobese patients with atrial fibrillation (AF) undergoing first catheter ablation88 men
Participants
116 patients
Exposure
Body size metrics and fat parameters and left atrial (LA) reverse remodeling
Outcome
Lack of LARR (<15% reduction or increase in LA volume index)
Follow-up
6 months after CA

Main finding

As reported in the abstract

Lack of LARR (multivariable analysis)

Adjusted odds ratio

3.86

P < 0.01

W/H ratio · per 0.10 increase

Adjusted odds ratio

2.81

P < 0.01

CF% · per 10% increase

Observational data: associations, not effects.

Further findings

Baseline LA size

Body size metrics and adiposity measures not independently associated with baseline LA size

LA enlargement 6 months after catheter ablation (CA)

Higher W/H ratio and CF% groups had persistent LA enlargement vs counterparts
both P < 0.01

Combined CF% and W/H ratio

Complementary risk stratification for persistent LA enlargement

Original publication

Body Fat Distribution and Left Atrial Reverse Remodeling After Catheter Ablation for Atrial Fibrillation. JACC Adv. Published 6 May 2024. doi:10.1016/j.jacadv.2024.100973

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