Heart failure & cardiomyopathies
Body surface potential mapping detects early disease onset in plakophilin-2-pathogenic variant carriers
Authors' conclusion
Assessing depolarization and repolarization by BSPM may help in the quest for early detection of disease in variant carriers since abnormal QRS- and/or STT-patterns were found in variant carriers with a normal 12 lead ECG.
Study context
- Population
- PKP2-pathogenic variant carriers (arrhythmogenic right ventricular cardiomyopathy (ARVC)) and control subjects
- Participants
- 42 vs 25
- Exposure
- PKP2-pathogenic variant carriers vs controls
- PKP2-pathogenic variant carriersn = 42
- Controlsn = 25reference
- Outcome
- Abnormal QRS- and/or STT-patterns on BSPM isopotential map series
Methodological detailsRight ventricular (RV) echocardiographic deformation imaging, Subject-specific CT/MRI-based heart/torso models with electrode positions
- RV echocardiographic deformation imaging
- Subject-specific CT/MRI-based heart/torso models with electrode positions
Main finding
As reported in the abstract
Variant carriers with abnormal patterns (5 distinct abnormal QRS-patterns, 4 distinct abnormal STT-patterns)
31 of 42
Of these 31, no depolarization or repolarization abnormalities on 12-lead electrocardiogram (ECG)
17
Pre-clinical variant carriers with normal RV-deformation patterns
12 of 19
Of these 12, abnormal QRS- and/or STT-patterns
7 of 12
Observational data: associations, not effects.
Further findings
Pre-clinical variant carriers with normal RV-deformation patterns
- Pre-clinical carriers with normal RV-deformation patterns
- 12 of 19
- Of these, abnormal QRS- and/or STT-patterns on body surface potential mapping (BSPM)
- 7/12
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →