Arrhythmias & electrophysiologyMeta-analysis
Bone mineral loss and risk of atrial fibrillation: a multicohort study
- Population-based cohort study with random-effects meta-analysis
- three independent cohorts
- Cox proportional hazard models
- random-effect meta-analysis
Authors' conclusion
This research revealed an increased risk of AF in individuals with osteoporosis, especially in males.
Study context
- Population
- Population-based participants from three independent cohorts
- Participants
- 495,549 participants · 3 cohorts
- Comparison
- Osteoporosis vs no osteoporosis
- Outcome
- Incident AF
Pooled result
AF
Hazard ratio
1.38
95% CI 1.01–1.89
Osteoporosis vs Without osteoporosis
HR 1.38 (95% CI 1.01–1.89)
As reported in the abstract
Further pooled results
| Outcome | HR (95% CI) | |
|---|---|---|
| AF by sex (primary cohort) — Osteoporosis vs Without osteoporosis · males | 1.30 (1.11–1.51) | |
| AF by sex (primary cohort) — Osteoporosis vs Without osteoporosis · females | 1.16 (1.04–1.28) | |
| 0.512Hazard ratio (log scale) |
Circulating proteins
- Proteins contributing to osteoporosis–atrial fibrillation (AF) relationship
- 19
- LMNB2 improved predictive accuracy for AF incidence
Original publication
Bone mineral loss and risk of atrial fibrillation: a multicohort study. Eur J Prev Cardiol. Published 12 June 2025. doi:10.1093/eurjpc/zwaf346
Summarised from the published abstract; every number is checked against it