Arrhythmias & electrophysiology
Peri-Atrial Adipose Tissue Inflammation in Atrial Fibrillation: Quantification of Electrophysiological Effects Using Electroanatomic Mapping
Main finding · Peri-atrial adipose tissue volumeResult — go to the resultAdjusted odds ratio 1.11 95% CI 1.01–1.24Authors' conclusion
Peri-atrial adipose tissue volume was greater in patients with AF. Increased peri-atrial adipose tissue burden and reduced attenuation were spatially but weakly correlated with adverse electrophysiological remodeling in patients with AF.
Study context
- Population
- Control subjects and patients with AF undergoing cardiac CTA
- Participants
- 44 vs 37
- Comparison
- Mean adipose tissue volume and attenuation were compared with local voltage and conduction velocity measurements.
- Patients with AFn = 44
- Control subjectsn = 37
- Outcome
- Peri-atrial adipose tissue volume
Main finding
As reported in the abstract
Adjusted odds ratio
1.11
95% CI 1.01–1.24
By group
Patients with AF
adjusted odds ratio 1.11 (95% CI 1.01–1.24)
Further findings
| Outcome | Areas with the highest burden | Areas with the lowest burden |
|---|---|---|
| Voltage and conduction velocity, highest vs lowest peri-atrial adipose tissue burden areas (patients with AF)Lower with highest burden | ||
| Voltage | 1.75 ± 1.72 mV | 2.11 ± 2.02 mV |
| Conduction velocity | 0.627 ± 0.55 ms-1 | 0.683 ± 0.48 ms-1 |
- Voltage and conduction velocity, highest vs lowest peri-atrial adipose tissue burden areas (patients with AF): voltage P < 0.001
- Voltage and conduction velocity, highest vs lowest peri-atrial adipose tissue burden areas (patients with AF): conduction velocity P < 0.001
Mean peri-atrial adipose tissue attenuation
- Similar in both groups
Low peri-atrial adipose tissue attenuation vs bipolar voltage and conduction velocity (patients with AF)
- Bipolar voltage
- 1.69 ± 1.68 mV vs 2.16 ± 2.07 mV; P < 0.001
- Conduction velocity
- 0.615 ± 0.47 ms-1 vs 0.684 ± 0.43 ms-1; P < 0.001
- Weakly correlated
Original publication
Peri-Atrial Adipose Tissue Inflammation in Atrial Fibrillation: Quantification of Electrophysiological Effects Using Electroanatomic Mapping. JACC Clin Electrophysiol. Published 11 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →