Breast Artery Calcification for Primary Prevention of Major Adverse Cardiovascular Outcomes in Women
Authors' conclusion
The use of the pooled cohort equations to risk stratify women for MACE underestimates risk in women with a low predicted risk. BAC is independently associated with an increased risk of MACE and may be useful as an incremental risk modifier.
Study context
- Population
- Women aged 40 to 75 without coronary artery disease who underwent a routine screening mammogram
- Participants
- 1,216 women
- Exposure
- Women with breast artery calcification (BAC) vs women without BAC
- BACn = 232
- Outcome
- Major adverse cardiovascular events (MACE)
- Follow-up
- 10 years
Methodological detailsconsecutive women, Dartmouth Health, 2011 to 2012, 10 years of follow-up
- Consecutive women
- Dartmouth Health
- 2011 to 2012
- 10 years of follow-up
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Incidence
| Outcome | BAC | Without BAC | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| MACE among women with low (<5%) risk by pooled cohort equations (subgroup) | 18% | 7% | 2.8 (1.5–5.0) | P = 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Breast Artery Calcification for Primary Prevention of Major Adverse Cardiovascular Outcomes in Women. JACC Adv. Published 29 April 2026. doi:10.
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