Remote Ischemic Preconditioning Prevents Acute Kidney Injury Following Coronary Angiography: The BRICK Randomized Clinical Trial
Primary result · Rate of AKI after coronary angiographyResult — go to the resultOdds ratio 0.43 95% CI 0.17–0.94Authors' conclusion
In high-risk patients undergoing coronary angiography, RIPC reduced incidence of AKI and MACCE, and positively influenced biomarkers of kidney injury. (Biochemical Effects of Remote Ischemic Pre-Conditioning on Contrast-induced Acute Kidney Injury [BRICK]; NCT03236441).
Study context
- Population
- High-risk patients undergoing invasive coronary angiography, March 2018 to February 2023randomized, median age, 75 years
- Participants
- 109 patients
- Comparison
- Remote ischemic preconditioning (RIPC) vs sham-RIPC
- RIPCn = 54
- sham-RIPCn = 55reference
- Primary endpoint
- Rate of acute kidney injury (AKI) after coronary angiography
Methodological detailsrandomly assigned 1:1
- Randomly assigned 1:1
Primary result
As reported in the abstract
Odds ratio
0.43
95% CI 0.17–0.94
P = 0.030
By group
RIPCvs sham-RIPC
OR 0.43 (95% CI 0.17–0.94); P = 0.030
Secondary outcomes
| Outcome | RIPC | sham-RIPC | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| MACCE · 6-month follow-up | 16.7% | 36.4% | 0.35 (0.14–0.87) | P = 0.029 | |
| Major adverse kidney events · 6-month follow-up | 7.4% | 10.4% | 0.65 (0.17–2.46) | P = 0.740 | |
| 0.10.31310Odds ratio (log scale) |
| Outcome | RIPC | sham-RIPC |
|---|---|---|
| Product of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein-7, pre-angiography vs 48 hours post-angiography | pre vs post 0.39 vs 0.68 | pre vs post 0.51 vs 0.89 |
- Product of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein-7, pre-angiography vs 48 hours post-angiography: sham-RIPC: significant increase, P = 0.004
- Product of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein-7, pre-angiography vs 48 hours post-angiography: RIPC: P = 0.091
Original publication
Remote Ischemic Preconditioning Prevents Acute Kidney Injury Following Coronary Angiography: The BRICK Randomized Clinical Trial. JACC Adv. Published 23 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →