Arrhythmias & electrophysiology
Burden of cardiometabolic disorders and lifetime risk of new-onset atrial fibrillation among men and women: the Rotterdam Study
Authors' conclusion
We observed a significant combined impact of cardiometabolic disorders on AF risk, in particular among women. Participants with cardiometabolic multimorbidity had a significantly higher lifetime risk of AF, especially at a young index age.
Study context
- Population
- Men and women free of atrial fibrillation (AF) at baseline (1996–2008), population-based Rotterdam Study4,101 men · 5421 women
- Exposure
- Burden of cardiometabolic disorders, by sex
- Outcome
- New-onset AF and remaining lifetime risk of AF
- Follow-up
- Median 12.8 years
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
New-onset AF per larger burden of cardiometabolic disorders
Hazard ratio (95% CI)
Larger burden (women)women; fully adjusted
1.33(1.22–1.46)
Larger burden (men)men; fully adjusted
1.18(1.08–1.29)
Per larger burden of cardiometabolic disorders, as printed
Observational data: associations, not effects.
Further findings
Percent
0
27.1%(95% CI 20.8–33.4)
1
26.5%(95% CI 22.8–30.5)
2
29.9%(95% CI 26.7–33.2)
3
30.8%(95% CI 25.7–35.8)
≥4
33.3%(95% CI 23.1–43.6)
Percent
0
15.8%(95% CI 10.5–21.2)
1
23.0%(95% CI 19.8–26.2)
2
29.7%(95% CI 26.8–32.6)
3
26.2%(95% CI 20.8–31.6)
≥4
34.2%(95% CI 17.3–51.1)
Original publication
Burden of cardiometabolic disorders and lifetime risk of new-onset atrial fibrillation among men and women: the Rotterdam Study. Eur J Prev Cardiol. Published 2 February 2024. doi:10.
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